Which condition is NOT treated by ACE inhibitors?

ACE inhibitors, or angiotensin-converting enzyme inhibitors, are primarily used in the management of cardiovascular conditions. They work by inhibiting the conversion of angiotensin I to angiotensin II, a peptide that narrows blood vessels and can increase blood pressure. By blocking this conversion, ACE inhibitors help to lower blood pressure, reduce the workload on the heart, and improve survival in patients with heart failure.

In the context of kidney disease, ACE inhibitors are beneficial because they can help protect renal function, particularly in patients with diabetic nephropathy or hypertension. They can reduce proteinuria and slow the progression of kidney injury.

Depression, on the other hand, is a mental health condition that does not respond to the pharmacological actions of ACE inhibitors. This class of medication does not target the neurotransmitters or pathways associated with mood regulation, which is why it is not indicated as a treatment for depression. Therefore, the option referring to depression is the one that is not treated by ACE inhibitors, as their therapeutic effects are focused on cardiovascular and renal health.